The endoplasmic reticulum (ER) is a subcellular organelle that is responsible for numerous functions including calcium homeostasis, protein secretion and lipid biosynthesis. However, cell death signaling pathways can be activated by prolonged stress to the ER originating from sources ranging from hypoxia, oxidative injury, high-fat diet, hypoglycaemia, protein inclusion bodies and viral infection. In fact, a [...]
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