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Archive for November, 2008

choice work hours from the good old days

This was a really cool post I recently read called “Invertebrate Time”.  It will really hit home for all of us who have had the freedom to keep random work hours in pursuit of answers, come and go whenever, reducing life to (in my case it was): sleep, eat, lab/research, gym (in no particular order) [...]

choosing a research topic

So you’ve decided to do research and are wondering what to do it in.  Two pointers that I picked up during graduate school are: 1) do research in something you are passionate about and 2) do research in something that is important to the lay-person.  Okay, so where do I get this from?  I ended up [...]

world aids day 2008

December 1 will be the 20th World AIDS Day.  Take some time to think about the fact that over 30 million people are infected with HIV worldwide–as well as the tragic extent of the AIDS epidemic in Sub-Saharan Africa, where 2/3rds of the world’s HIV+ population live and 2/3rds of AIDS-related deaths occur. For more [...]

game on

Okay, funding opportunities are searchable now.  It’s a work in progress!

the balance of the universe is restored

I had a shift in the ER today–11am to 7pm.  Not entirely thrilled to be working on the day after thanksgiving.  But, I knew it was going to be a good day when I got to the garage at the hospital and the best parking space (closest to the exit to the hospital–you all know [...]

aortic dissection

This is an 82 yr old woman I saw in the ER today.  Came in for an ingrown pubic hair–of all things–and received a cautionary chest x-ray just as she was heading out the door (long story) and was incidentally found to have a widened mediastinum (one of the things to look for on a chest [...]

mulligan

Okay, I may have spoken too soon about the funding opportunities page. They’re all up there but the code for the search is not working, so you can’t narrow down the grants by status yet. Sorry–I’m working on it. I will be working in the ER tomorrow (better than going today I suppose) but will [...]

funding opportunities

Funding opportunities for medical students, graduate students, post-docs, residents, clinical fellows and investigators are now up and searchable.  I will be adding many more in the coming weeks–all with direct links to the actual grant applications and/or information urls. Still working on making it more user friendly, but it is use-able for now.

happy thanksgiving

To go to work or not to go to work?  That is the question.  The ultimate dilemma.  Of course, if you are in the medical field, there is no question–you’re either on or off.   But if you are in the lab, do you go in for that quick experiment before your thanksgiving day meal?  I [...]

reality check

Hilarious bordering on uncomfortably absurd.  Final Countdown by Europe.  Take 5 minutes, sit back and enjoy…   Europe-The Final Countdown @ Yahoo! Video

warfarin (coumadin) management guidelines

Managing a patient on warfarin (coumadin) can be very tricky, as warfarin metabolism is very complex and affected by many factors including genetics, food, medical problems and current medications.  Moreover, the therapeutic window is often relatively narrow–usually in the range of INR = 2.0 to 3.5.  If you are managing a patient starting or on warfarin, [...]

had a thesis committee meeting recently?

Yes, thesis committee meetings can be such a hassle. Depending on when your last meeting was (if ever), you may have to go over months or years worth of data, positive and negative results (bringing back all of those bad memories)–and then assimilate it all into a presentation. Sadly, you have to come to terms [...]

western blotting reagent recipes

All reagents for western blot are mostly purchased by labs, but if you still make your own reagents, here are some recipes I used during graduate school. These reagents are compatible with all pre-made gels. If you really want a recipe for SDS protein gels, let me know… 10x Transfer Buffer (1L): 144g Glycine 30g [...]

mudphudder life update

So this is how I spend my time off.  I am currently in a 2 week stretch without clinical rotation and off from residency interviews for another week and a half.  Fortunately or unfortunately, I’ve got a number of manuscripts to wrap up.  Making progress but it’s the final details that makes writing a manuscript such a [...]

where to buy sodium borate electrophoresis buffer

There was some interest in the sodium borate buffer DNA electrophoresis so I thought that I would look around for companies that sell the stuff.  I actually had a hard time finding anyone who sells sodium borate electrophoresis buffer (e.g. couldn’t find it in Invitrogen, Biorad, etc.), but the company Labsupplymall does sell a 20X [...]

medical students not socializing enough?

Check out this post on Dr. Shock’s blog on a recent study that medical students are socially segregated from others.  In my experience, medical training by its nature is very intensive.  I wouldn’t want to go to a doctor who wasn’t intensively trained.  Most people wouldn’t.  That said, the practice of medicine is also a [...]

early loss of mycobacterium tuberculosis–specific helper t cell responses after HIV infection

HIV+ individuals have increased susceptibility to becoming infected with tuberculosis. In fact, a second epidemic of tuberculosis has arisen in the last decade due to the increasing number of people who are immunodeficient from HIV infection. In contrast to many opportunistic infections which occur in late-stage HIV infection (or AIDS), increased tuberculosis susceptibility occurs when [...]

structure of PPAR-gamma bound to DNA

From Chandra et al in the November 20 issue of the journal Nature: The peroxisome proliferator-activated receptors (PPARs) are composed of separately encoded genes (PPAR-alpha, PPAR-beta/delta and PPAR-gamma) that have overlapping tissue expression but overall are important regulators of various metabolic pathways, controling cellular processes such as regulation of lipid and carbohydrate metabolism. PPAR-gamma is [...]

sodium borate nucleic acid electrophoresis buffer

Sodium Borate Electrophoresis Buffer (SBE buffer) is an excellent alternative to traditional TBE (TRIS borate-EDTA) and TAE (TRIS acetate-EDTA) electrophoresis buffers. SBE buffer allows for higher voltage runs, extremely rapid running times, and high-resolution band separation. Brody and Kern described sodium borate buffer for nucleic acid electrophoresis several years ago (Sodium boric acid: a Tris-free, [...]

informed-consent law enacted by south dakota to restrict abortion

A new informed-consent law in effect as of July in the state of South Dakota states that any physician performing an abortion must provide the following information to the pregnant woman: (1) A statement in writing providing the following information: (a) The name of the physician who will perform the abortion; (b) That the abortion [...]

busy busy

I hope everyone is doing well and getting ready for a nice Thanksgiving. For those of you who have to work on Thanksgiving, I know it’s a real bummer. I may be working in the ER on Thanksgiving too. It’s a busy time of year. 4th year medical students are running around on the interview [...]

underlying relationships of multi-university collaborations in academics

In the last 30 years, more and more published scientific articles are a result of collaborations between investigators at different universities, which may suggest a dissemination of research beyond the walls of a few elite universities and/or geographic regions.  A study published in the Nov. 21st issue of the journal Science finds that increased multi-university [...]

gordon research conferences

Every year there are many “Gordon Research Conferences,” each on different topics related to the biological and physical sciences.  These conferences are generally limited to small numbers of attendees that includes graduate students, post-docs, and faculty members who are some of the world’s leaders in those fields. If you can find a Gordon Conference on a topic you are [...]

a conference for MD/PhD students

Understanding the Past, Transforming the Future:    National Conference for Physician-Scholars in the Social Sciences and Humanities     Philadelphia, Pennsylvania     March 28-29, 2009    http://scholarsinmedicine.blogspot.com/     This coming spring, MD/PhD candidates and graduates in the humanities and social sciences are pleased to be hosting a nation-wide gathering for social science and humanities MD/PhD students and graduates. Registration for the [...]

physicians/scientists perform the first trachea transplant

Reported online on November 18 on the website of the journal Lancet, physicians from the Hospital Clinic in Barcelona, Spain reported the first trachea transplant.  The transplant trachea that was transplanted was produced from a segment of donor trachea that was denuded of donor cells, leaving a cartilage matrix, and subsequently reseeded with chondrocytes derived from bone marrow [...]

pediatric blunt splenic trauma

This is a slice from an abdominal CT scan of a 14 yr old kid I saw in the ER who was walking across the street when he was hit by a truck which threw him in front of another truck that hit him as well: This kid suffered a grade 4 splenic injury (one [...]

career resources for PhDs

The situation for scientists is becoming constantly more tenuous with increasingly more competition at all levels: in graduate school, as a post-doc and on the job.  Advice on everything from succeeding in graduate school, as a post-doc, writing cover letters, getting and exceling at a job in academia as well as industry is offered at: http://www.phds.org/career-resources.  [...]

predicting microRNA binding sites

Are you interested in or researching microRNA regulation of gene expression?  MicroInspector (written by Vesselin Baev and Ventsislav Rusinov at the University of Plovdiv in Bulgaria) is a web-based program that predicts the existence of microRNA binding sites in a given sequence (you can enter the actual sequence or GENBANK accession number) for many different organisms [...]

standard questions to ask faculty during residency interviews

Obviously you will probably have your own personal questions to ask faculty during your residency interviews, but if you are ever at a loss for questions to ask, here are some safe ones: What medical schools do the current residents come from? What is the success rate of graduates on specialty boards/fellowship spots/finding jobs? What [...]

funding opportunities for medical and graduate students: grants, research, and fellowships

I have updated the funding opportunities page with a new and easy to read/search format that includes grants, funded research opportunities and fellowships. Keep checking because I will be adding a ton of new content to the funding opportunities page in the next few weeks!